Chronic exposure to a high-fat diet induces hepatic steatosis, impairs nitric oxide bioavailability, and modifies the mitochondrial proteome in mice.

@article{Eccleston2011ChronicET,
  title={Chronic exposure to a high-fat diet induces hepatic steatosis, impairs nitric oxide bioavailability, and modifies the mitochondrial proteome in mice.},
  author={Heather B. Eccleston and Kelly K. Andringa and Angela M. Betancourt and Adrienne L. King and Sudheer Kumar Mantena and Telisha Millender Swain and Heather Nicole Tinsley and R Nicholas Nolte and Tim R Nagy and Gary A Abrams and Shannon M. Bailey},
  journal={Antioxidants & redox signaling},
  year={2011},
  volume={15 2},
  pages={447-59}
}
Obesity-related pathologies, such as nonalcoholic fatty liver disease, are linked to mitochondrial dysfunction and nitric oxide (NO) deficiency. Herein, we tested the hypothesis that a high-fat diet (HFD) modifies the liver mitochondrial proteome and alters proteins involved in NO metabolism, namely arginase 1 and endothelial NO synthase. Male C57BL/6 mice were fed a control or HFD and liver mitochondria were isolated for proteomics and reactive oxygen species measurements. Steatosis and… CONTINUE READING
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