Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-beta 1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype.

Abstract

Transformed mouse epidermal keratinocytes of the cell line PDV, when cultured under the presence of transforming growth factor-beta 1 (TGF-beta 1), escaped the block of growth exerted by this factor in normal keratinocytes and underwent marked changes in cell differentiation. TGF-beta 1 induced disruption of epithelial interactions, dispersion of cells… (More)

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@article{Caulin1995ChronicEO, title={Chronic exposure of cultured transformed mouse epidermal cells to transforming growth factor-beta 1 induces an epithelial-mesenchymal transdifferentiation and a spindle tumoral phenotype.}, author={Ch. Caulin and Francisco G. Scholl and P Frontelo and Carlos Gamallo and Miguel A S Quintanilla}, journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research}, year={1995}, volume={6 8}, pages={1027-35} }