Chronic exposure of astrocytes to interferon-α reveals molecular changes related to Aicardi-Goutieres syndrome.

@article{Cuadrado2013ChronicEO,
  title={Chronic exposure of astrocytes to interferon-α reveals molecular changes related to Aicardi-Goutieres syndrome.},
  author={Eloy Cuadrado and M. H. Jansen and Jasper J. Anink and Lidia de Filippis and Angelo L. Vescovi and Catherine O. Watts and E. Aronica and Elly M Hol and Taco W Kuijpers},
  journal={Brain : a journal of neurology},
  year={2013},
  volume={136 Pt 1},
  pages={
          245-58
        }
}
Aicardi-Goutières syndrome is a genetically determined infantile encephalopathy, manifesting as progressive microcephaly, psychomotor retardation, and in ∼25% of patients, death in early childhood. Aicardi-Goutières syndrome is caused by mutations in any of the genes encoding TREX1, RNASEH2-A, -B, -C and SAMHD1, with protein dysfunction hypothesized to result in the accumulation of nucleic acids within the cell, thus triggering an autoinflammatory response with increased interferon-α production… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 61 REFERENCES

Clinical and molecular phenotype of Aicardi-Goutieres syndrome.

  • American journal of human genetics
  • 2007
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL