Chronic exercise decreases sensitivity to mu opioids in female rats: correlation with exercise output.

@article{Smith2006ChronicED,
  title={Chronic exercise decreases sensitivity to mu opioids in female rats: correlation with exercise output.},
  author={Mark A. Smith and Megan A. Lyle},
  journal={Pharmacology, biochemistry, and behavior},
  year={2006},
  volume={85 1},
  pages={12-22}
}
Aerobic exercise stimulates the release of endogenous opioid peptides and increases nociceptive (i.e., pain) threshold in a naloxone-reversible manner. During chronic exercise, sensitivity to the antinociceptive effects of morphine and other mu opioids decreases, leading some investigators to propose that exercise may lead to the development of cross-tolerance to exogenously administered opioid agonists. The purpose of the present study was to examine the effects of chronic exercise on… CONTINUE READING
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