Chronic ethanol treatment impairs Rac and Cdc42 activation in rat hepatocytes.

  title={Chronic ethanol treatment impairs Rac and Cdc42 activation in rat hepatocytes.},
  author={Courtney S Schaffert and Sandra L. Todero and Carol A. Casey and Geoffrey M Thiele and Michael F. Sorrell and Dean J. Tuma},
  journal={Alcoholism, clinical and experimental research},
  volume={30 7},
BACKGROUND The effects of chronic ethanol feeding on rat hepatocytes have been shown to include impaired cell-extracellular matrix (ECM) adhesion events, such as decreased attachment and spreading as well as increased integrin-actin cytoskeleton association. These results, observed previously by this laboratory, are highly suggestive of impaired actin cytoskeleton reorganization, an event mediated by differential activation of the Rho family GTPases Rac, Cdc42, and RhoA. Therefore, the purpose… CONTINUE READING


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