Chronic ethanol produces increased taurine transport and efflux in cultured astrocytes.

  title={Chronic ethanol produces increased taurine transport and efflux in cultured astrocytes.},
  author={J. Allen and L. Mutkus and M. Aschner},
  volume={23 6},
  • J. Allen, L. Mutkus, M. Aschner
  • Published 2002
  • Chemistry, Medicine
  • Neurotoxicology
  • Due to ethanol's low potency and low level of toxicity, high amounts of ethanol are consumed to achieve pharmacological effects. Blood levels of ethanol in chronic alcoholics may reach as high as 80-100 mM. We undertook a series of studies to determine if these high levels of ethanol stimulated osmoregulatory processes in cultured astrocytes. The uptake and efflux of taurine, the major osmoregulatory amino acid with potentially neuroprotective actions, was assessed. In addition, uptake and… CONTINUE READING
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