Chronic ethanol produces a decreased sensitivity to the response-disruptive effects of GABA receptor complex antagonists

@article{Rassnick1993ChronicEP,
  title={Chronic ethanol produces a decreased sensitivity to the response-disruptive effects of GABA receptor complex antagonists},
  author={S. Rassnick and Jolie Krechman and G. Koob},
  journal={Pharmacology Biochemistry and Behavior},
  year={1993},
  volume={44},
  pages={943-950}
}
  • S. Rassnick, Jolie Krechman, G. Koob
  • Published 1993
  • Chemistry, Medicine
  • Pharmacology Biochemistry and Behavior
  • Disruption of responding for food reinforcement may reflect the motivational state subsequent to the onset of an aversive event and has previously been shown to be sensitive to spontaneous withdrawal from ethanol and precipitated opiate withdrawal. The purpose of this study was to attempt to precipitate ethanol withdrawal with bicuculline methiodide, a competitive GABAA receptor antagonist, and Ro 15-4513, a benzodiazepine inverse agonist. A quantitative operant measure of food-motivated… CONTINUE READING
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    References

    SHOWING 1-10 OF 50 REFERENCES
    The startle response in rats: effect of ethanol
    • 63
    Acute and chronic ethanol treatments alter GABA receptor-operated chloride channels
    • 255
    Alcohol withdrawal reactions in mice: effects of drugs that modify neurotransmission.
    • D. B. Goldstein
    • Chemistry, Medicine
    • The Journal of pharmacology and experimental therapeutics
    • 1973
    • 215
    Tolerance to the discriminative stimulus effects of ethanol.
    • 18
    Benzodiazepine agonist and inverse agonist actions on GABAA receptor-operated chloride channels. II. Chronic effects of ethanol.
    • K. Buck, R. Harris
    • Chemistry, Medicine
    • The Journal of pharmacology and experimental therapeutics
    • 1990
    • 162