• DOI:10.1016/0091-3057(93)90029-S
Corpus ID: 5909253

Chronic ethanol produces a decreased sensitivity to the response-disruptive effects of GABA receptor complex antagonists

@article{Rassnick1993ChronicEP,
  title={Chronic ethanol produces a decreased sensitivity to the response-disruptive effects of GABA receptor complex antagonists},
  author={S. Rassnick and Jolie Krechman and G. Koob},
  journal={Pharmacology Biochemistry and Behavior},
  year={1993},
  volume={44},
  pages={943-950}
}

S. Rassnick, Jolie Krechman, G. Koob

Published 1993

Chemistry, Medicine

Pharmacology Biochemistry and Behavior

Disruption of responding for food reinforcement may reflect the motivational state subsequent to the onset of an aversive event and has previously been shown to be sensitive to spontaneous withdrawal from ethanol and precipitated opiate withdrawal. The purpose of this study was to attempt to precipitate ethanol withdrawal with bicuculline methiodide, a competitive GABAA receptor antagonist, and Ro 15-4513, a benzodiazepine inverse agonist. A quantitative operant measure of food-motivated… CONTINUE READING

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