Chronic ethanol-mediated decrease in cAMP primes macrophages to enhanced LPS-inducible NF-kappaB activity and TNF expression: relevance to alcoholic liver disease.

@article{Gobejishvili2006ChronicED,
  title={Chronic ethanol-mediated decrease in cAMP primes macrophages to enhanced LPS-inducible NF-kappaB activity and TNF expression: relevance to alcoholic liver disease.},
  author={Leila N Gobejishvili and Shirish S. Barve and Swati Joshi-Barve and Silvia Uriarte and Zhenyuan Song and C J Mcclain},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2006},
  volume={291 4},
  pages={G681-8}
}
Increased plasma and hepatic TNF-alpha activity has been implicated in the pathogenesis of alcoholic liver disease (ALD). We previously reported that monocytes from alcoholic patients show enhanced constitutive as well as LPS-inducible NF-kappaB activation and TNF-alpha production. Studies in monocytes have shown that cAMP plays an important role in regulating TNF-alpha expression, and elevation of cellular cAMP suppresses TNF-alpha production. The effects of chronic ethanol exposure on the… CONTINUE READING

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