Chronic ethanol ingestion increases susceptibility to acute lung injury: role of oxidative stress and tissue remodeling.

@article{Guidot2002ChronicEI,
  title={Chronic ethanol ingestion increases susceptibility to acute lung injury: role of oxidative stress and tissue remodeling.},
  author={David M. Guidot and Jesse Roman},
  journal={Chest},
  year={2002},
  volume={122 6 Suppl},
  pages={309S-314S}
}
Clinical studies have demonstrated that chronic alcohol abuse is an independent outcome variable in acute lung injury. The Emory Center for the Study of Acute Lung Injury is determining the mechanisms by which ethanol increases susceptibility to acute lung injury. We developed a rat model of chronic ethanol ingestion and demonstrated that ethanol predisposes rats to edematous lung injury elicited by endotoxemia or sepsis. Chronic ethanol ingestion in rats led to decreased levels of glutathione… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Pathophysiology of acute lung injury and the acute respiratory distress syndrome.

Seminars in respiratory and critical care medicine • 2006
View 7 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 27 references

Ethanol - induced fibronectin expression in lung fibroblasts : implications for ARDS [ abstract ]

J Roman, JD Ritzenthaler, S Roser
Am J Respir Crit Care Med • 2002

Chronic ethanol ingestion potentiates TNF - mediated oxidative stress and apoptosis in rat alveolar type II cells

Brown LAS, FL Harris, DM Guidot
Am J Physiol Lung Cell Mol Physiol • 2001

The effects of chronic alcohol abuse on pulmonary glutathione homeostasis.

American journal of respiratory and critical care medicine • 2000

Similar Papers

Loading similar papers…