Chronic ethanol increases fetal cerebral blood flow specific to the ethanol‐sensitive cerebellum under normoxaemic, hypercapnic and acidaemic conditions: ovine model

@article{Parnell2007ChronicEI,
  title={Chronic ethanol increases fetal cerebral blood flow specific to the ethanol‐sensitive cerebellum under normoxaemic, hypercapnic and acidaemic conditions: ovine model},
  author={S. E. Parnell and J. Ramadoss and M. Delp and M. W. Ramsey and W. Chen and J. West and T. Cudd},
  journal={Experimental Physiology},
  year={2007},
  volume={92}
}
  • S. E. Parnell, J. Ramadoss, +4 authors T. Cudd
  • Published 2007
  • Medicine, Biology
  • Experimental Physiology
  • Cerebral hypoxia has been proposed as a mechanism by which prenatal ethanol exposure causes fetal alcohol spectrum disorder (FASD) in children, but no study had tested this hypothesis using a chronic exposure model that mimicks a common human exposure pattern. Pregnant sheep were exposed to ethanol, 0.75 or 1.75 g kg−1 (to create blood ethanol concentrations of 85 and 185 mg dl−1, respectively), or saline 3 days per week in succession (a ‘binge drinking’ model) from gestational day (GD) 109… CONTINUE READING
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