Chronic ethanol feeding induces cellular antioxidants decrease and oxidative stress in rat peripheral nerves. Effect of S-adenosyl-L-methionine and N-acetyl-L-cysteine.

@article{BoschMorell1998ChronicEF,
  title={Chronic ethanol feeding induces cellular antioxidants decrease and oxidative stress in rat peripheral nerves. Effect of S-adenosyl-L-methionine and N-acetyl-L-cysteine.},
  author={Francisco Bosch-Morell and Francisco Mart{\'i}nez-Soriano and Anna Colell and Jos{\'e} C Fern{\'a}ndez-Checa and Francisco Javier Romero},
  journal={Free radical biology & medicine},
  year={1998},
  volume={25 3},
  pages={365-8}
}
Chronic ethanol feeding promotes oxidative stress in rat peripheral nerve. Malondialdehyde, a lipid peroxidation product, content increases in sciatic nerves of rats fed an ethanol-containing diet, when compared with pair-fed animals. Moreover, glutathione content and glutathione peroxidase activity in this same tissue decrease in ethanol-fed vs. pair-fed rats. S-Adenosyl-L-methionine and N-acetyl-L-cysteine, both with possible therapeutic action on alcoholism, were tested in this animal model… CONTINUE READING

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