Chronic ethanol drinking reduces native T-type calcium current in the thalamus of nonhuman primates

@article{Carden2006ChronicED,
  title={Chronic ethanol drinking reduces native T-type calcium current in the thalamus of nonhuman primates},
  author={Wm Breckinridge Carden and Georgia M Alexander and David P. Friedman and James B. Daunais and Dwayne W. Godwin},
  journal={Brain Research},
  year={2006},
  volume={1089},
  pages={92-100}
}
BACKGROUND Chronic ethanol use is known to disrupt normal sleep rhythms, but the cellular basis for this disruption is unknown. An important contributor to normal sleep patterns is a low-threshold calcium current mediated by T-type calcium channels. The T-type calcium current underlies burst responses in thalamic nuclei that are important to spindle propagation, and we recently observed that this current is sensitive to acute low doses of ethanol. METHODS We used a combination of current… CONTINUE READING
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