Chronic ethanol consumption results in atypical liver injury in copper/zinc superoxide dismutase deficient mice.

@article{CurryMcCoy2010ChronicEC,
  title={Chronic ethanol consumption results in atypical liver injury in copper/zinc superoxide dismutase deficient mice.},
  author={Tiana V Curry-McCoy and Natalia A Osna and Amin A. Nanji and Terrence M. Donohue},
  journal={Alcoholism, clinical and experimental research},
  year={2010},
  volume={34 2},
  pages={251-61}
}
BACKGROUND Ethanol metabolism increases production of reactive oxygen species, including superoxide (O2(.-)) in the liver, resulting in significant oxidative stress, which causes cellular damage. Superoxide dismutase (SOD) is an antioxidant enzyme that converts superoxide to less toxic intermediates, preventing accumulation. Because the absence of SOD would confer less resistance to oxidative stress, we determined whether damage to hepatic proteolytic systems was greater in SOD(-/-) than in SOD… CONTINUE READING
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