Chronic ethanol consumption increases the amount of mRNA for retinoic acid and triiodothyronine receptors in mouse brain.

@article{Alfos1996ChronicEC,
  title={Chronic ethanol consumption increases the amount of mRNA for retinoic acid and triiodothyronine receptors in mouse brain.},
  author={Serge Alfos and Paul Higueret and V{\'e}ronique Pallet and Denise Higueret and H. Garcin and Robert Jaffard},
  journal={Neuroscience letters},
  year={1996},
  volume={206 2-3},
  pages={73-6}
}
It is known that alcohol induces disorders in the metabolism of retinoids and particularly in the biosynthetic pathways of retinoic acid (RA). Since RA has, along with other hormones and particularly triiodothyronine (T3), a physiological role in the adult brain, the effect of chronic exposure to alcohol on RA and T3 status was investigated. The amounts of RA receptor (RAR) and T3 receptor (TR) mRNAs were quantified and the activity of the 'tissue' transglutaminase (tTG; an RA-dependent enzyme… CONTINUE READING