Chronic ethanol consumption decreases serum sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice

@article{Kanbe2013ChronicEC,
  title={Chronic ethanol consumption decreases serum sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice},
  author={Hiroki Kanbe and Yuji Kamijo and Toshiaki Nakajima and Naoki Tanaka and Eiko Sugiyama and Lixuan Wang and Zhong-Ze Fang and Atsushi Hara and Frank J. Gonzalez and Toshifumi Aoyama},
  journal={Archives of Toxicology},
  year={2013},
  volume={88},
  pages={367-379}
}
Epidemiological studies demonstrate a possible relationship between chronic ethanol drinking and thrombotic diseases, such as myocardial infarction and stroke. However, the precise mechanism for this association remains unclear. Sulfatides are endogenous glycosphingolipids composed of ceramide, galactose, and sulfate, known to have anti-thrombotic properties. Low (0.5 g/kg/day), middle (1.5 g/kg/day), and high (3.0 g/kg/day) doses of ethanol were administered for 21 days intraperitoneally to… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

Activation of PPARα by Fatty Acid Accumulation Enhances Fatty Acid Degradation and Sulfatide Synthesis.

  • The Tohoku journal of experimental medicine
  • 2016
VIEW 3 EXCERPTS
CITES METHODS
HIGHLY INFLUENCED

Heavy ethanol consumption aggravates the ischemic cerebral injury by inhibiting ALDH2.

  • International journal of stroke : official journal of the International Stroke Society
  • 2015

Roles of galactose 3′-O- sulfation in signaling

  • Glycoconjugate Journal
  • 2014
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 53 REFERENCES

Acute kidney injury induced by protein-overload nephropathy down-regulates gene expression of hepatic cerebroside sulfotransferase in mice, resulting in reduction of liver and serum sulfatides

Z Xiaowei, T Nakajima, +6 authors A Hara
  • Biochem Biophys
  • 2009
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Acute kidney injury induced by protein-overload nephropathy down-regulates gene expression of hepatic cerebroside sulfotransferase in mice, resulting in reduction of liver and serum sulfatides

Z Xiaowei, T Nakajima, +6 authors A Hara
  • Biochem Biophys
  • 2009
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL