Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice.

@article{Arbeit1996ChronicEC,
  title={Chronic estrogen-induced cervical and vaginal squamous carcinogenesis in human papillomavirus type 16 transgenic mice.},
  author={Jeffrey Arbeit and Peter M Howley and Douglas Hanahan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 7},
  pages={2930-5}
}
High-risk human papillomaviruses (HPVs), including type 16, have been identified as factors in cervical carcinogenesis. However, the presence and expression of the virus per se appear to be insufficient for carcinogenesis. Rather, cofactors most likely are necessary in addition to viral gene expression to initiate neoplasia. One candidate cofactor is prolonged exposure to sex hormones. To examine the possible effects of estrogen on HPV-associated neoplasia, we treated transgenic mice expressing… CONTINUE READING
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Trends Microbiol

  • M. M. Pater, R. Mittal, A. Pater
  • 1994

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