Chronic estrogen deficiency leads to molecular aberrations related to neurodegenerative changes in follitropin receptor knockout female mice.

@article{Tam2002ChronicED,
  title={Chronic estrogen deficiency leads to molecular aberrations related to neurodegenerative changes in follitropin receptor knockout female mice.},
  author={Joseph Tam and Natalia Danilovich and Kenneth Nilsson and M. Ram Sairam and Dusica Maysinger},
  journal={Neuroscience},
  year={2002},
  volume={114 2},
  pages={493-506}
}
The follitropin receptor knockout (FORKO) mouse undergoes ovarian failure, thereby providing an animal model to investigate the consequences of the depletion of circulating estrogen in females. The estrogen deficiency causes marked defects in the female reproductive system, obesity, and skeletal abnormalities. In light of estrogen's known pleiotropic… CONTINUE READING