Chronic estradiol exposure modulates thyroid structure and decreases T4 and T3 serum levels in middle-aged female rats.

@article{oiJurjevi2005ChronicEE,
  title={Chronic estradiol exposure modulates thyroid structure and decreases T4 and T3 serum levels in middle-aged female rats.},
  author={Branka T {\vS}o{\vs}i{\'c}-Jurjevi{\'c} and Branko Filipovi{\'c} and Verica Lj. Milo{\vs}evi{\'c} and Nata{\vs}a Nestorovi{\'c} and Milica N. Manojlovi{\'c}-Stojanoski and Branislava Brki{\'c} and Milka I. Sekuli{\'c}},
  journal={Hormone research},
  year={2005},
  volume={63 1},
  pages={48-54}
}
OBJECTIVES In human medicine, estrogen is applied in prevention and treatment of health problems associated with the menopause. The aim of this study was to examine the effects of chronic estradiol dipropionate (EDP) treatment on thyroid gland structure and function in middle-aged female rats. METHODS At 14 months of age, Wistar rats received 0.625 mg EDP/kg b.w./day intraperitoneally for 2 weeks. The peripheral and central zones of the thyroid were stereologically analyzed and the following… CONTINUE READING

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