Chronic epidural bupivacaine-opioid infusion in intractable cancer pain.

  title={Chronic epidural bupivacaine-opioid infusion in intractable cancer pain.},
  author={Stuart L Du Pen and Evan D. Kharasch and Adrienne J. Williams and Daniel G. Peterson and Denis C Sloan and H Hasche-Klunder and A W Krembs},
  volume={49 3},
This study examined the efficacy and toxicity associated with chronic epidural opioid-bupivacaine infusions. In a series of 68 patients with cancer pain refractory to epidural opioids alone, analgesia was effectively regained by infusing a opioid-bupivacaine combination. Sixty-one patients (90%) were considered treatment successes, according to conventional criteria. Median length of therapy was 60-120 days, with the longest infusion lasting 277 days. Chronic bupivacaine infusion concentrations… CONTINUE READING