Chronic eosinophilic leukemias and the myeloproliferative variant of the hypereosinophilic syndrome.

@article{Bain2007ChronicEL,
  title={Chronic eosinophilic leukemias and the myeloproliferative variant of the hypereosinophilic syndrome.},
  author={Barbara J Bain and S. E. H. Fletcher},
  journal={Immunology and allergy clinics of North America},
  year={2007},
  volume={27 3},
  pages={377-88}
}
Among patients with hypereosinophilia, a myeloproliferative variant is recognized. In many of these patients a diagnosis of eosinophilic leukemia can be made. The molecular mechanism is often a fusion gene, incorporating part of PDGFRA or PDGFRB, encoding anaberrant tyrosine kinase. Prompt diagnosis of such cases is important since specific tyrosine kinase inhibitor therapy is indicated. 

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