Chronic enteral ethanol treatment causes hypoxia in rat liver tissue in vivo

@article{Arteel1997ChronicEE,
  title={Chronic enteral ethanol treatment causes hypoxia in rat liver tissue in vivo},
  author={Gavin E. Arteel and Yuji Iimuro and Ming Yin and James A. Raleigh and Ronald G. Thurman},
  journal={Hepatology},
  year={1997},
  volume={25}
}
It is known that ethanol increases oxygen consumption in in vitro liver models, which could lead to hypoxia. Although it was shown recently that one large dose of ethanol caused hypoxia in rat liver in vivo, whether ethanol produces hypoxia in a clinically relevant chronic model remains unclear. In the present study, therefore, the effect of chronic ethanol on hypoxia was investigated in vivo using the 2‐nitroimidazole hypoxia marker, pimonidazole. Male Wistar rats (300‐325 g) were exposed to… 
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