Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity

Abstract

Proper function of the endoplasmic reticulum (ER) and mitochondria is crucial for cellular homeostasis, and dysfunction at either site has been linked to pathophysiological states, including metabolic diseases. Although the ER and mitochondria play distinct cellular roles, these organelles also form physical interactions with each other at sites defined as… (More)
DOI: 10.1038/nm.3735

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Cite this paper

@article{Arruda2014ChronicEO, title={Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity}, author={Ana Paula Arruda and Benedicte Mengel Pers and G{\"u}neş Parlakg{\"u}l and Ekin G{\"u}ney and Karen E. Inouye and G{\"o}khan S Hotamisligil}, journal={Nature Medicine}, year={2014}, volume={20}, pages={1427-1435} }