Chronic endothelin receptor antagonism preserves coronary endothelial function in experimental hypercholesterolemia.

@article{Best1999ChronicER,
  title={Chronic endothelin receptor antagonism preserves coronary endothelial function in experimental hypercholesterolemia.},
  author={Patricia Best and Charles J McKenna and David Hasdai and David R. Holmes and Amir Lerman},
  journal={Circulation},
  year={1999},
  volume={99 13},
  pages={1747-52}
}
BACKGROUND Endothelin-1 (ET-1) is an endothelium-derived peptide that constricts coronary vessels through stimulation of the ET-A and ET-B receptors. Experimental porcine hypercholesterolemia is associated with impaired coronary endothelial function and elevated ET-1 concentrations. This study was designed to test the hypothesis that chronic endothelin receptor antagonism preserves coronary endothelial function in experimental hypercholesterolemia. METHODS AND RESULTS Acetylcholine (10(-6) to… CONTINUE READING

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