Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes.

@article{Ishibashi2001ChronicET,
  title={Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes.},
  author={Ken-ichi Ishibashi and Takuji Imamura and Prem Mohini Sharma and J Huang and Satoshi Ugi and Jerrold M. Olefsky},
  journal={The Journal of clinical investigation},
  year={2001},
  volume={107 9},
  pages={1193-202}
}
We recently reported that insulin and endothelin-1 (ET-1) can stimulate GLUT4 translocation via the heterotrimeric G protein G alpha q/11 and through PI3-kinase--mediated pathways in 3T3-L1 adipocytes. Because both hormones stimulate glucose transport through a common downstream pathway, we determined whether chronic ET-1 pretreatment would desensitize these cells to acute insulin signaling. We found that ET-1 pretreatment substantially inhibited insulin-stimulated 2-deoxyglucose uptake and… CONTINUE READING

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