Chronic embryonic MK-801 exposure disrupts the somatotopic organization of cutaneous nerve projections in the chick spinal cord.

@article{Mendelson1994ChronicEM,
  title={Chronic embryonic MK-801 exposure disrupts the somatotopic organization of cutaneous nerve projections in the chick spinal cord.},
  author={B Mendelson},
  journal={Brain research. Developmental brain research},
  year={1994},
  volume={82 1-2},
  pages={152-66}
}
  • B Mendelson
  • Published 1994 in Brain research. Developmental brain research
The effect of altering neural activity on the development of the central projections of cutaneous and muscle sensory neurons was studied in the embryonic chick spinal cord. Animals were treated chronically with MK-801, a non-competitive N-methyl-D-aspartate receptor antagonist, during the period when both cutaneous and muscle sensory afferents form connections in the spinal cord. Daily applications of MK-801 began on embryonic day 5, 1 day before sensory collaterals penetrate the spinal cord… CONTINUE READING