Chronic electromagnetic field exposure decreases HSP70 levels and lowers cytoprotection

@article{Carlo2002ChronicEF,
  title={Chronic electromagnetic field exposure decreases HSP70 levels and lowers cytoprotection},
  author={A. D. Di Carlo and N. White and Fuling Guo and P. Garrett and T. Litovitz},
  journal={Journal of Cellular Biochemistry},
  year={2002},
  volume={84}
}
Electromagnetic field (EMF) exposures have been shown to induce heat shock proteins (HSPs), which help to maintain the conformation of cellular proteins during periods of stress. We have previously reported that short‐term exposure of chick embryos to either 60 Hz (extremely low frequency: ELF), or radio‐frequency (RF: 915 MHz) EMFs induce protection against hypoxia. Experiments presented in the current report are based on a study in which long‐term (4 days), continuous exposure to ELF‐EMFs… Expand
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TLDR
Exposure to a 1950 MHz RF field has no effect on cell proliferation and expression of Hsp 27 and Hsp70, but it may inhibit the phosphorylation of HSp27 at Serine 78 in MO54 cells. Expand
EXPOSURE TO 2.45 GHz MICROWAVE RADIATION PROVOKES CEREBRAL CHANGES IN INDUCTION OF HSP-90 fi/fl HEAT SHOCK PROTEIN IN RAT
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TLDR
Data show that high density ELF-MF only induce reversible brain DNA damage while they do not affect hsp70 expression, showing a dose-response relationship among exposure to extremely low frequency magnetic fields and 70-kDa heat shock protein expression and DNA damage in mouse brain. Expand
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References

SHOWING 1-10 OF 59 REFERENCES
Myocardial protection conferred by electromagnetic fields.
TLDR
It is concluded that athermal EM field exposures induce stress responses that protect chick embryo myocardium from anoxia damage and may be a useful, noninvasive means of minimizing myocardial damage during surgery, transplantation, or heart attack in humans. Expand
Application of magnetic field–induced heat shock protein 70 for presurgical cytoprotection
TLDR
This investigation investigated the optimal exposure conditions for magnetic field induction of hsp70 for presurgical cytoprotection and found that when cells underwent a 20‐min exposure followed by repeated 20-min exposures (restimulation) with different field strengths, additional increases in hsp60 levels were induced. Expand
Short-term magnetic field exposures (60 Hz) induce protection against ultraviolet radiation damage.
TLDR
It is demonstrated that EM field exposures of appropriate duration induce protection against damage from UV light exposure, and stress proteins are thought to play a role in the observed UV protection. Expand
Reduction of heat‐shock protein‐70 after prolonged treatment with retinoids: Biological and clinical implications
TLDR
Reduced production of HSP‐70 caused by ATRA and by 9‐cis RA, though to a lesser extent, could render the cells more sensitive to cytotoxic agents and could provide the rationale for the efficacy of ATRA + chemotherapy combinations. Expand
Increased levels of hsp70 transcripts induced when cells are exposed to low frequency electromagnetic fields
TLDR
The model of cell interaction with electric and/or magnetic fields appears to be related to the stress response model for heat shock, as shown in yeast and yeast cells. Expand
Induction of stress proteins by electromagnetic fields in cultured HL-60 cells.
HL-60 cells in culture were exposed for 2 h to a sinusoidal 0.1 or 1 mT (1 or 10 Gauss) magnetic field at 60 Hz and pulse labeled after exposure with radioactive isotopes by incubation by usingExpand
Electromagnetic field stimulation of biosynthesis: changes in c-myc transcript levels during continuous and intermittent exposures
Abstract We studied the effects of continuous and single limited exposures of HL60 cells to 60 Hz electromagnetic (EM) fields. Results showed an increase in transcript levels for c-myc peaks after 20Expand
Electromagnetic field exposure induces rapid, transitory heat shock factor activation in human cells
TLDR
The events mediating the electromagnetic field–stimulated stress response appear to be similar to those reported for other physiological stresses (e.g., hyperthermia, heavy metals, oxidative stress) and could well be the general mechanism of interaction of electromagnetic fields with cells. Expand
Heat shock protein 27 expression in human proximal tubule cells exposed to lethal and sublethal concentrations of CdCl2.
TLDR
Findings imply that hsp 27 expression in human proximal tubule cells may have two distinct modes depending on the nature (acute vs. chronic) of the stress. Expand
Magnetic field exposure enhances mRNA expression of σ32 in E. coli
TLDR
The hypothesis that the cells respond to MFs in a manner similar to other environmental stressors such as heat is examined, showing that the intracellular level of σ32 mRNA is enhanced following a 15‐min exposure to a 60 Hz, 1.1 mT magnetic field. Expand
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