Chronic effects of tranylcypromine and 4-fluorotranylcypromine on regional brain monoamine metabolism in rats: a comparison with clorgyline.

@article{Greenshaw1989ChronicEO,
  title={Chronic effects of tranylcypromine and 4-fluorotranylcypromine on regional brain monoamine metabolism in rats: a comparison with clorgyline.},
  author={A. J. Greenshaw and Tadimeti S. Rao and Adil J. Nazarali and Glen B Baker and Ronald Thomson Coutts},
  journal={Biological psychiatry},
  year={1989},
  volume={25 8},
  pages={1014-20}
}
A regional analysis of brain amine and acid metabolite levels was conducted after chronic administration of the antidepressant tranylcypromine (0.5 mg/kg/day), of a novel fluorinated analog of this compound, and of clorgyline (1.0 mg/kg/day). These compounds were administered to male Sprague-Dawley rats for 28 days by subcutaneous infusion using osmotic… CONTINUE READING