Chronic effect of parathyroid hormone on NHE3 expression in rat renal proximal tubules.

@article{Girardi2000ChronicEO,
  title={Chronic effect of parathyroid hormone on NHE3 expression in rat renal proximal tubules.},
  author={Adriana C. C. Girardi and Silvia Maria de Oliveira Titan and Gerhard Malnic and Nancy Amaral Rebouças},
  journal={Kidney international},
  year={2000},
  volume={58 4},
  pages={1623-31}
}
BACKGROUND The most abundant Na+/H+ exchanger in the apical membrane of proximal tubules is the type 3 isoform (NHE3), and its activity is acutely inhibited by parathyroid hormone (PTH). In the present study, we investigate whether changes in protein abundance as well as in mRNA levels play a significant role in the long-term modulation of NHE3 by PTH. METHODS Three groups of animals were compared: (1) HP: animals submitted to hyperparathyroidism by subcutaneous implantation of PTH pellets… CONTINUE READING
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