Chronic effect of losartan in a murine model of dilated cardiomyopathy: comparison with captopril.

@article{Kanda1995ChronicEO,
  title={Chronic effect of losartan in a murine model of dilated cardiomyopathy: comparison with captopril.},
  author={Takeshi Kanda and Masahiko Araki and Mika Nakano and Shigemitsu Imai and Tadashi Suzuki and Kazuya Murata and Isao Kobayashi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={273 2},
  pages={955-8}
}
The long-term effects of losartan, an angiotensin II subtype-I receptor antagonist, were compared with those of captopril in a murine model of dilated cardiomyopathy caused by encephalomyocarditis virus. Four weeks after viral inoculation, 42 DBA/2 mice were given oral losartan 1.2 mg/kg/day (n = 8), 12 mg/kg/day (n = 8) or 60 mg/kg/day (n = 8) or captopril 7.5 mg/kg/day (n = 8) in drinking water or distilled water (n = 10). Mice were killed at the end of the 12-wk treatment period. Heart… CONTINUE READING