Chronic distress, age-related neuropathology, and late-life dementia.

  title={Chronic distress, age-related neuropathology, and late-life dementia.},
  author={Robert Smith Wilson and Steven E Arnold and Julie A Schneider and Yan Li and David A. Bennett},
  journal={Psychosomatic medicine},
  volume={69 1},
OBJECTIVE The objective of this study was to test whether common age-related neuropathology could account for the relation of chronic distress to dementia. METHODS In a selected cohort of more than 1000 older Catholic clergy members undergoing annual clinical evaluations, 326 persons died, of whom 306 (94%) underwent brain autopsy, the results of which were available in 219 (mean age at death = 85.4, standard deviation [SD] = 6.6; mean postmortem interval = 7.6 hours, SD = 6.9). A composite… CONTINUE READING


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