Chronic dietary toxicity/oncogenicity studies on 2,4-dichlorophenoxyacetic acid in rodents.

@article{Charles1996ChronicDT,
  title={Chronic dietary toxicity/oncogenicity studies on 2,4-dichlorophenoxyacetic acid in rodents.},
  author={Jeffrey M. Charles and David M. Bond and T K Jeffries and Barry L. Yano and W. T. Stott and K A Johnson and Helen C. Cunny and R. D. Wilson and James S. Bus},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1996},
  volume={33 2},
  pages={
          166-72
        }
}
  • J. CharlesD. M. Bond J. Bus
  • Published 1996
  • Medicine
  • Fundamental and applied toxicology : official journal of the Society of Toxicology
Forms of 2,4-dichlorophenoxyacetic acid (collectively known as 2,4-D) are herbicides used to control a wide variety of broadleaf and woody plants. Doses in the 2-year chronic/oncogenicity rat study were 0, 5, 75, and 150 mg/kg/day. The chronic toxicity paralleled subchronic findings, and a NOEL of 5 mg/kg/day was established. A slight increase in astrocytomas observed (in males only) at 45 mg/kg/day in a previously conducted chronic rat study was not confirmed in the present study at the high… 

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