Chronic dietary toxicity/oncogenicity studies on 2,4-dichlorophenoxyacetic acid in rodents.

@article{Charles1996ChronicDT,
  title={Chronic dietary toxicity/oncogenicity studies on 2,4-dichlorophenoxyacetic acid in rodents.},
  author={J. Charles and D. M. Bond and T. Jeffries and B. Yano and W. Stott and K. Johnson and H. Cunny and R. Wilson and J. Bus},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1996},
  volume={33 2},
  pages={
          166-72
        }
}
  • J. Charles, D. M. Bond, +6 authors J. Bus
  • Published 1996
  • Medicine
  • Fundamental and applied toxicology : official journal of the Society of Toxicology
Forms of 2,4-dichlorophenoxyacetic acid (collectively known as 2,4-D) are herbicides used to control a wide variety of broadleaf and woody plants. Doses in the 2-year chronic/oncogenicity rat study were 0, 5, 75, and 150 mg/kg/day. The chronic toxicity paralleled subchronic findings, and a NOEL of 5 mg/kg/day was established. A slight increase in astrocytomas observed (in males only) at 45 mg/kg/day in a previously conducted chronic rat study was not confirmed in the present study at the high… Expand
Comparative metabolism of 2,4-dichlorophenoxyacetic acid (2,4-D) in rat and dog
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The results show that the body burden of 2,4-D in dog is significantly higher than in rat for an equivalent dose, which is consistent with the increased sensitivity of dog to 2, 4-D toxicity. Expand
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The scientific evidence in humans and animals relevant to cancer risks, neurologic disease, reproductive risks, and immunotoxicity of 2,4-D was reviewed and no experimental evidence exists supporting the theory that 2, 4-D or any of its salts and esters damages DNA under physiologic conditions. Expand
Sex-dependent differences in the disposition of 2,4-dichlorophenoxyacetic acid in Sprague-Dawley rats, B6C3F1 mice, and Syrian hamsters.
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Kinetic analysis revealed significant differences in elimination and exposure parameters consistent with a greater ability to clear 2,4-D by male rats relative to females, which suggests that at equivalent doses, female rats are exposed to higher concentrations of 2, 4-D for a longer time than males and may be more susceptible to 2,3-D-induced toxicity. Expand
Exposures to 2,4-Dichlorophenoxyacetic acid with or without endotoxin upregulate small cell lung cancer pathway
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The data from the study provide the insights of the potential damage on lungs caused by 2,4-D and help to better understand the mechanism of this complex relation. Expand
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The results suggest that the 2,4-D has a neurotoxic action in the neurons from the myenteric plexus, interfering in the myEnteric neuronal density, when different population of these neurons are compared. Expand
THE EFFECT OF 2,4-D ON GENE EXPRESSION IN CULTURED CELLS
The cytotoxic effects of exposure to low concentrations of the herbicide, 2,4dichlorophenoxyacetic acid (2,4-D) that are typically found in groundwater were investigated, in vitro. Most 2,4-DExpand
A Systematic Review of Carcinogenic Outcomes and Potential Mechanisms from Exposure to 2,4-D and MCPA in the Environment
TLDR
A comparison of biomonitoring data to oral equivalent doses calculated from bioassay data shows that environmental exposures are not sufficient to support a causal relationship and the combined evidence does not support a genotoxic mode of action. Expand
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Overall, there were fewer cancer cases than expected, and a non statistically significant increase in the number of NHL cases, and no clear patterns of NHL risk with period of hire and histology subtypes. Expand
Assessment of diurnal systemic dose of agrochemicals in regulatory toxicity testing--an integrated approach without additional animal use.
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TK analyses in the study animals is now included in all short- (excluding acute), medium- and long-term guideline mammalian toxicity studies including reproduction/developmental tests and is used to select the most appropriate method of oral administration for test materials for rat and rabbit developmental toxicity studies. Expand
Neurons of the Myenteric Plexus of the Rat Ileum Are Vulnerable to the Action of the Herbicide 2,4-Dichlorophenoxyacetic Acid
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Results suggest that 2,4-D causes a reduction in neuronal density, particularly for cholinergic neurons, and promotes an increase in the cell body area of nitrergic neurons, leading to hypertrophy. Expand
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Modern computing equipment is extremely fast and can also provide graphical out-put. Prior to the computer era, problems were often formulated in terms of a single numerical criterion which could beExpand
Chronic dietary toxicity/oncogenicity studies on 2,4-dichlorophenoxyacetic acid in the rodents
  • J. S. Fundam. Appl. Toxicol
  • 1996
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