Chronic dietary pergolide preserves nigrostriatal neuronal integrity in aged-Fischer-344 rats.

@article{Felten1992ChronicDP,
  title={Chronic dietary pergolide preserves nigrostriatal neuronal integrity in aged-Fischer-344 rats.},
  author={David L. Felten and Scott Felten and Ray W. Fuller and T D Romano and E. Barry Smalstig and David T. Wong and James A. Clemens},
  journal={Neurobiology of aging},
  year={1992},
  volume={13 2},
  pages={339-51}
}
Pergolide, a potent D2 presynaptic agonist with postsynaptic D2 agonist activity and some D1 agonist activity was administered in the diet (0.5 mg/kg/day) of male Fischer 344 rats from age 3 to age 26 months. We hypothesized that the potent D2 presynaptic activity would reduce the baseline release of dopamine (DA) and thereby slow the formation of toxic oxidative metabolites that lead to age-related deterioration of nigrostriatal DA neurons. Pair-fed rats served as controls. We observed age… CONTINUE READING

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