Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptin-deficient APP/PS1 mice

@inproceedings{Zhang2017ChronicDS,
  title={Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptin-deficient APP/PS1 mice},
  author={Shuai Zhang and Rui Chai and Ying-Ying Yang and Shi-Qi Guo and Shan Wang and Tian Guo and Shuang-Feng Xu and Yan-Hui Zhang and Zhan-You Wang and Chuang Guo},
  booktitle={Oncotarget},
  year={2017}
}
The coincidences between Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are so compelling that it is attractive to speculate that diabetic conditions might aggravate AD pathologies by calcium dysfunction, although the understanding of the molecular mechanisms involved remains elusive. The present work was undertaken to investigate whether… CONTINUE READING