Chronic dexamethasone treatment suppresses hypertension development in the transgenic rat TGR(mREN2)27.

Abstract

INTRODUCTION The transgenic rat TGR(mREN2)27 is a monogenetic rat model in hypertension research. Integration of mouse Ren-2 gene into the rat genome led to fulminant hypertension despite suppressed plasma and kidney renin concentrations. Renin is highly expressed in extrarenal tissues, especially throughout the adrenal cortex. AIMS AND METHODS Because… (More)

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