Chronic developmental lead exposure increases the threshold for long-term potentiation in rat dentate gyrus in vivo.

@article{Gilbert1996ChronicDL,
  title={Chronic developmental lead exposure increases the threshold for long-term potentiation in rat dentate gyrus in vivo.},
  author={Mary E. Gilbert and Cina M Mack and Stephen M. Lasley},
  journal={Brain research},
  year={1996},
  volume={736 1-2},
  pages={118-24}
}
Chronic developmental lead (Pb) exposure has been long associated with cognitive dysfunction in children and animals. In an attempt to more directly relate the behavioral observations of impaired cognitive ability to Pb-induced effects on neuronal activity, we utilized the long-term potentiation (LTP) model of neural plasticity to assess synaptic function. Male rats were chronically exposed to 0.2% Pb(2+)-acetate through the drinking water of the pregnant dam, and directly through their own… CONTINUE READING
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