Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen

@article{Bajtner2005ChronicDO,
  title={Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen},
  author={Estelle Bajtner and Kutty Selva Nandakumar and {\AA}ke Engstr{\"o}m and Rikard Holmdahl},
  journal={Arthritis Research & Therapy},
  year={2005},
  volume={7},
  pages={R1148 - R1157}
}
Antibodies against type II collagen (CII) are important in the development of collagen-induced arthritis (CIA) and possibly also in rheumatoid arthritis. We have determined the fine specificity and arthritogenicity of the antibody response to CII in chronic relapsing variants of CIA. Immunization with rat CII in B10.Q or B10.Q(BALB/cxB10.Q)F2 mice induces a chronic relapsing CIA. The antibody response to CII was determined by using triple-helical peptides of the major B cell epitopes. Each… CONTINUE READING

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