Chronic dermal studies of petroleum streams in mice.

  title={Chronic dermal studies of petroleum streams in mice.},
  author={W D Broddle and Michael W. Dennis and D N Kitchen and E H Vernot},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  volume={30 1},
During petroleum refining, a large number of products are generated which have varying chemical and physical properties. These are known in the industry as petroleum streams. In order to characterize their carcinogenic activity, a number of these commercially produced streams were administered to C3H/HeJ mice in chronic dermal bioassays. The bioassays were conducted using one of two study designs: the first set of test materials was applied for a lifetime and the second set for 24 months. In… CONTINUE READING


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