Chronic delta9-tetrahydrocannabinol treatment produces a time-dependent loss of cannabinoid receptors and cannabinoid receptor-activated G proteins in rat brain.

@article{Breivogel1999ChronicDT,
  title={Chronic delta9-tetrahydrocannabinol treatment produces a time-dependent loss of cannabinoid receptors and cannabinoid receptor-activated G proteins in rat brain.},
  author={Christopher S Breivogel and Steven R. Childers and Sam A. Deadwyler and Robert E. Hampson and Leslie J. Vogt and L. J. Sim-Selley},
  journal={Journal of neurochemistry},
  year={1999},
  volume={73 6},
  pages={2447-59}
}
Chronic treatment of rats with delta9-tetrahydrocannabinol (delta9-THC) results in tolerance to its acute behavioral effects. In a previous study, 21-day delta9-THC treatment in rats decreased cannabinoid activation of G proteins in brain, as measured by in vitro autoradiography of guanosine-5'-O-(3-[35S]thiotriphosphate) ([35S]GTPgammaS) binding. The present study investigated the time course of changes in cannabinoid-stimulated [35S]GTPgammaS binding and cannabinoid receptor binding in both… CONTINUE READING

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