Chronic deep brain stimulation of the lateral habenula nucleus in a rat model of depression.

@article{Meng2011ChronicDB,
  title={Chronic deep brain stimulation of the lateral habenula nucleus in a rat model of depression.},
  author={Hongmei Meng and Yanan Wang and Min Huang and Weihong Lin and Shao Wang and Baimin Zhang},
  journal={Brain research},
  year={2011},
  volume={1422},
  pages={32-8}
}
In the present study, we aim to determine the antidepressant effects of chronic deep brain stimulation (DBS) of the lateral habenula nucleus (LHb) in a rat model of depression and to explore the potential mechanism of DBS induced improvement of depressive symptoms. To establish the rat depression model, animals were repeatedly exposed to a set of chronic mild stressors for four consecutive weeks. The open-field and sucrose consumption tests were used as measures of depression. For DBS treatment… CONTINUE READING
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