Chronic deep brain stimulation in the rat nucleus accumbens and its effect on morphine reinforcement.

@article{Liu2008ChronicDB,
  title={Chronic deep brain stimulation in the rat nucleus accumbens and its effect on morphine reinforcement.},
  author={Hong-yu Liu and Jie Jin and Jing-shi Tang and Wei Sun and Hong Bo Jia and Xin-ping Yang and Jian-mei Cui and Chen-guang Wang},
  journal={Addiction biology},
  year={2008},
  volume={13 1},
  pages={40-6}
}
In order to explore a novel method for the treatment of drug abuse, we evaluated the effect of chronic deep brain stimulation (DBS) of the rat nucleus accumbens (NAc) on morphine reinforcement, using a DBS apparatus and an implant method we developed. Thirty-two adult rats weighing 240-260 g were divided into three groups, which included a DBS group (n = 10, administration of surgery, morphine and DBS), a sham DBS group (n = 12, administration of surgery and morphine) and a control group (n… CONTINUE READING

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