Chronic cyclic strain reduces adenylate cyclase activity and stimulatory G protein subunit levels in coronary smooth muscle cells.

Previous studies from this laboratory have demonstrated that acute cyclic strain causes a reduction in adenylate cyclase activity in cultured coronary vascular smooth muscle cells. The objective of this study was to test the hypothesis that chronic cyclic strain of coronary vascular smooth muscle cells also causes inhibition of adenylate cyclase activity… (More)