Chronic curcumin treatment normalizes depression-like behaviors in mice with mononeuropathy: involvement of supraspinal serotonergic system and GABAA receptor

@article{Zhao2013ChronicCT,
  title={Chronic curcumin treatment normalizes depression-like behaviors in mice with mononeuropathy: involvement of supraspinal serotonergic system and GABAA receptor},
  author={Xin Zhao and Chuang Wang and Jun-fang Zhang and Li Liu and Ai-Ming Liu and Qing Ma and Wen-hua Zhou and Ying Xu},
  journal={Psychopharmacology},
  year={2013},
  volume={231},
  pages={2171-2187}
}
Comorbid depression is commonly observed in individuals who suffer from neuropathic pain, which necessitates improved treatment. Curcumin, a phenolic compound derived from Curcuma longa, possesses both antinociceptive and antidepressant-like activities in animal studies, suggesting its possible usefulness in treating this comorbidity. We investigated the… CONTINUE READING
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