Chronic corticosterone treatment increases the endocannabinoid 2-arachidonylglycerol in the rat amygdala.

@article{Hill2005ChronicCT,
  title={Chronic corticosterone treatment increases the endocannabinoid 2-arachidonylglycerol in the rat amygdala.},
  author={Matthew Nicholas Hill and W S V Ho and Sarah E Meier and Boris B. Gorzalka and Cecilia J. Hillard},
  journal={European journal of pharmacology},
  year={2005},
  volume={528 1-3},
  pages={99-102}
}
This research was designed to examine the effect of three weeks of administration of corticosterone (20 mg/kg) on endocannabinoid content and cannabinoid CB1 receptor binding in the amygdala. It was found that the endocannabinoid 2-arachidonylglycerol was significantly increased in the amygdala following chronic corticosterone treatment. However, there was no change in either the maximal binding (Bmax) or binding affinity (KD) of [3H]-CP 55,940 to the CB1 receptor in the amygdala. Given the… CONTINUE READING

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