Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice.

@article{Hoot2010ChronicCI,
  title={Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice.},
  author={Michelle R Hoot and L. J. Sim-Selley and Justin L Poklis and Rehab A. Abdullah and Krista L Scoggins and D. E. Selley and William L. Dewey},
  journal={Brain research},
  year={2010},
  volume={1339},
  pages={18-25}
}
The present studies examined the effect of chronic neuropathic pain on cannabinoid receptor density and receptor-mediated G-protein activity within supraspinal brain areas involved in pain processing and modulation in mice. Chronic constriction injury (CCI) produced a significant decrease in WIN 55,212-2-stimulated [(35)S]GTPgammaS binding in membranes… CONTINUE READING