Chronic constipation.

@article{Lembo2003ChronicC,
  title={Chronic constipation.},
  author={A. Lembo and M. Camilleri},
  journal={The New England journal of medicine},
  year={2003},
  volume={349 14},
  pages={
          1360-8
        }
}
N Engl J Med 2003;349:1360-8. Copyright © 2003 Massachusetts Medical Society. onstipation is a common symptom affecting between 2 percent 1,2 and 27 percent 3 of the population in Western countries. In the United States, it results in more than 2.5 million visits to physicians, 92,000 hospitalizations, 2 and laxative sales of several hundred million dollars a year. Constipation is more prevalent in women than in men, 4 in nonwhites than in white persons, 5 in children than in adults, 6 and in… Expand
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Constipation appears to represent a permanent medical condition in the adult U.S. population, which has not changed in the past 28 years, and modern life-style, which should be associated with more sedentary occupations and consumption of processed food, did not appear to affect the occurrence of constipation. Expand
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Differences in epidemiological profile by age, sex ratio, and relation to other sociodemographical factors support the distinction of two and possibly more symptom-based subtypes of constipation. Expand
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Attention is drawn to this distinctive combination in young women of slow total gut transit time and a colon of normal width on barium enema, associated with abdominal, anorectal, gynaecological and somatic symptoms, as a disorder which can be disabling and particularly difficult to treat. Expand
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TLDR
Symptoms of chronically constipated patients are not well suited to differentiate between the pathophysiologic subgroups suffering chronic constipation; the symptom “necessity to strain” is much better suited. Expand
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TLDR
Oral colchicine (0.6 mg three times a day) therapy appears to be an a promising treatment for chronic constipation and a placebo-controlled trial is indicated to confirm these findings. Expand
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TLDR
At a tertiary center, slow transit physiology and visceral hypersensitivity typical of IBS are equally common and overlap heavily in constipated patients. Expand
Clinical response to dietary fiber treatment of chronic constipation.
TLDR
Slow GI transit and/or a disorder of defecation may explain a poor outcome of dietary fiber therapy in patients with chronic constipation. Expand
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In patients with constipation the prevalence of melanosis in rectal biopsies was evaluated in an attempt to correlate its occurrence with laxative consumption and intestinal stasis. Melanosis wasExpand
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The Rome II criteria for this disorder seem to be satisfactory, but modifications may be considered to allow for constipated subjects taking laxatives and to increase the number of qualifying symptoms. Expand
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