Chronic constipation: overview and challenges.

@article{Cook2009ChronicCO,
  title={Chronic constipation: overview and challenges.},
  author={I J Cook and Nicholas J Talley and Mark A Benninga and Sanjay S Rao and S Mark Scott},
  journal={Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society},
  year={2009},
  volume={21 Suppl 2},
  pages={1-8}
}
Despite its high prevalence and cost implications, our understanding of the pathophysiology of constipation remains primitive, and available therapies have limited efficacy. The purpose of this supplement is to address critically the reasons for the current lack of understanding and to propose avenues of future research to address these deficiencies. 

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