Chronic cold in adrenalectomized, corticosterone (B)-treated rats: facilitated corticotropin responses to acute restraint emerge as B increases.

@article{Akana1997ChronicCI,
  title={Chronic cold in adrenalectomized, corticosterone (B)-treated rats: facilitated corticotropin responses to acute restraint emerge as B increases.},
  author={Susan F. Akana and Mary F. Dallman},
  journal={Endocrinology},
  year={1997},
  volume={138 8},
  pages={3249-58}
}
Small elevations in corticosterone (B) administered exogenously exert potent inhibitory effects on both basal and stress-induced ACTH secretion. However, under conditions of chronic stress with chronic elevations in B, the hypothalamo-pituitary-adrenal system appears to balance the negative feedback signal of B with central neural facilitation so that the system remains fully responsive to acute stressors. In these studies, we tested whether: 1) circulating B concentrations affect responses to… CONTINUE READING
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