Chronic cold acclimation increases thermogenic capacity, non-shivering thermogenesis and muscle citrate synthase activity in both wild-type and brown adipose tissue deficient mice.

@article{Mineo2012ChronicCA,
  title={Chronic cold acclimation increases thermogenic capacity, non-shivering thermogenesis and muscle citrate synthase activity in both wild-type and brown adipose tissue deficient mice.},
  author={Patrick M. Mineo and Emily A Cassell and Margaret E Roberts and Paul J Schaeffer},
  journal={Comparative biochemistry and physiology. Part A, Molecular & integrative physiology},
  year={2012},
  volume={161 4},
  pages={395-400}
}
The purpose of this study was to determine whether chronic cold exposure would increase the aerobic capacity of skeletal muscle in UCP-dta mice, a transgenic line lacking brown adipose tissue (BAT). Wild type and UCP-dta mice were acclimated to either warm (23 °C), or cold (4 °C) conditions. Cold increased muscle oxidative capacity nearly equivalently in wild-type and UCP-dta mice, but did not affect the respiratory function of isolated mitochondria. Summit metabolism ( ̇V O2summit) and… CONTINUE READING
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