Chronic cocaine treatment decreases levels of the G protein subunits Gi alpha and Go alpha in discrete regions of rat brain.

@article{Nestler1990ChronicCT,
  title={Chronic cocaine treatment decreases levels of the G protein subunits Gi alpha and Go alpha in discrete regions of rat brain.},
  author={Eric J Nestler and Rosemarie Terwilliger and John R Walker and Kevin A. Sevarino and Ronald S Duman},
  journal={Journal of neurochemistry},
  year={1990},
  volume={55 3},
  pages={1079-82}
}
A possible role for G proteins in contributing to the chronic actions of cocaine was investigated in three rat brain regions known to exhibit electrophysiological responses to chronic cocaine: the ventral tegmental area, nucleus accumbens, and locus coeruleus. It was found that chronic, but not acute, treatment of rats with cocaine produced a small (approximately 15%), but statistically significant, decrease in levels of pertussis toxin-mediated ADP-ribosylation of Gi alpha and Go alpha in each… CONTINUE READING

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