Chronic cocaine-mediated changes in non-human primate nucleus accumbens gene expression.

@article{Freeman2001ChronicCC,
  title={Chronic cocaine-mediated changes in non-human primate nucleus accumbens gene expression.},
  author={Willard M Freeman and Michael A. Nader and Susan H. Nader and Daniel J. Robertson and Luisa Di Gioia and Shannon M Mitchell and James B. Daunais and Linda J. Porrino and David P. Friedman and Kent E. Vrana},
  journal={Journal of neurochemistry},
  year={2001},
  volume={77 2},
  pages={542-9}
}
Chronic cocaine use elicits changes in the pattern of gene expression within reinforcement-related, dopaminergic regions. cDNA hybridization arrays were used to illuminate cocaine-regulated genes in the nucleus accumbens (NAcc) of non-human primates (Macaca fascicularis; cynomolgus macaque), treated daily with escalating doses of cocaine over one year. Changes seen in mRNA levels by hybridization array analysis were confirmed at the level of protein (via specific immunoblots). Significantly up… CONTINUE READING
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